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Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
) - Differential ... (48-70%) Cold ... HA (paroxysmal cold ... hemoglobinuria) • Cold ... Disease Mixed-type
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Intravascular Hemolysis - Differential ... Diagnosis Algorithm ... • Cold AIHA ... Complement-Mediated • Cold ... #Diagnosis #Algorithm
Shock Types and Classification
DISTRIBUTIVE 66%
 • Sepsis/SIRS, anaphylaxis, adrenal insufficiency, liver failure, toxins, spinal/neurogenic
 • Warm
Shock Types and ... overdiuresis • Cold ... • MI, CHF • Cold ... tamponade • Cold ... #diagnosis #differential
Autoimmune Hemolytic Anemia (AIHA)

WARM AHA
- Primary - Idiopathics
- Secondary
Infectious
 • Viral- HIV, EBV, HCV, HEV
 •
Hemolytic Anemia (AIHA ... alpha-methyldopa COLD ... Hemolytic #Anemia #AIHA ... #Diagnosis #Differential ... #Algorithm
Shock Types - Classification
State of cellular and tissue hypoxia due to: reduced oxygen delivery, increased oxygen
Shock Types - Classification ... tachycardia, dyspnea, cold ... beriberi CARDIOGENIC (Cold ... ring OBSTRUCTIVE (Cold ... cardiomyopathy HYPOVOLEMIC (Cold
Shock Classification
Shock Definition: State of cellular and tissue hypoxia due to: reduced oxygen delivery, increased oxygen
tachycardia, dyspnea, cold ... CARDIOGENIC (Cold ... OBSTRUCTIVE (Cold ... HYPOVOLEMIC (Cold ... #management #cold
First-line therapies for Asthma, Asthma-COPD Overlap and COPD

The diagnosis of COPD, asthma, and ACO initially requires
Asthma, Asthma-COPD ... Overlap and COPD ... The diagnosis of COPD ... identification of the type ... ACO = asthma-COPD
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin ... Disease 3 Types ... Cold Agglutinins ... women • 15% of AIHA ... younger pts) Differential
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Differential Diagnosis ... Hypersplenism • AIHA ... : warm, cold, drug ... Hemolytic #Anemia #Differential ... Diagnosis #causes #classification
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Autoimmune: Warm AIHA ... , Cold AIHA, Transfusion ... #Hemolysis #Differential