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diagnosis management hematology classification emergencies mds myelodysplastic oncologic acidosis anemia anesthesia aplastic apml ascites bilateral cancer checklist clinical differentiation elevation
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
- Differential ... Hyperviscosity Syndrome ... neutrophil count < 500 cells ... : Tumor Lysis Syndrome ... #differential #
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... = funny-shaped cells ... old, ~10,000 new cases ... only curative treatment ... #hematology #oncology
Peri-operative Hyperthermia - Guidelines for Crises in Anaesthesia If prolonged or ≥ 39 C this is a
Treatment depends ... maintained fever CAUSES ... • Serotonin syndrome ... #Hyperthermia #Differential ... #Causes #Anesthesiology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Out Secondary Causes ... factor (GCSF) treatments ... blood count with differential ... marrow studies Treatment ... diagnosis #hematology #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... and petechiae Causes ... Constitutional Syndromes ... aplastic anemia Treatment ... Aplastic #Anemia #oncology
Intermittent Bilateral Exophthalmos (Alternating Exophthalmos and Enophthalmos) on Physical Exam Observing this patient in silence for a
Exophthalmos (Alternating ... Treatments are aimed ... The syndrome of ... Differentials for ... Bilateral #clinical #video
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 Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Rhabdomyolysis - Differential ... Management Summary Causes ... kidney tubular cells ... Rhabdomyolysis #Differential ... Diagnosis #Management #causes
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Release from blast cells ... initiation • Differential ... management #hematology #oncology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Summary of Oncologic ... Treat underlying cause ... “big & sticky” cells ... → no immediate treatment ... #Emergencies #Oncology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... e.g., uptake by cells ... perfusion - shock->treatments ... before beginning treatment ... - Compartment syndrome
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