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diagnosis differential nephrology pharmacology binders cardiology classification comparison digoxin hypokalemia intercellularshift k management medications pathophysiology treatment
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
phlebotomy High ... • Recent IV potassium ... • Beta blockers ... differential #diagnosis #causes ... #potassium #high
The Diagnostic Approach to Hyperkalemia Drugs - Amiloride - Spironolactone - Triamterene - Trimethoprim - Pentamidine -
inhibitors Other causes ... transplant - SLE High ... - NSAlDs - Beta-Blockers ... #Hyperkalemia ... #Algorithm #diagnosis
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
phlebotomy High ... • Recent IV potassium ... • Beta blockers ... differential #diagnosis #causes ... #potassium #high
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... patients sensitive to high ... of aspiration #Potassium ... #Binding #Hyperkalemia ... #pharmacology #table
Causes of Hyperkalemia - Differential Diagnosis Framework • Cellular Shift: - Exercise
Causes of Hyperkalemia ... - Medications: beta ... blockers, digitalis ... Differential #Diagnosis #Causes ... #potassium #high
Digoxin Pharmacology and Pathophysiology 1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
works by directly binding ... - When digoxin blocks ... intracellular calcium causes ... - Hyperkalemia ( ... high potassium levels
Causes of Hyperkalemia - Reduced Excretion - Differential Diagnosis Algorithm Reduced flow through distal nephron - TTKG
Causes of Hyperkalemia ... Differential Diagnosis Algorithm ... • ENaC blockers ... nephropathy • Beta ... #Causes
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
ARBs, NSAIDs, β-blockers ... only if no clear cause ... Elimination (see Table ... Treatments: • K-Binding ... Management #Treatment #potassium
Causes of Hyperkalemia l. Pseudohyperkalemia A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis B.
Causes of Hyperkalemia ... Beta-Adrenergic ... Differential #Diagnosis #High ... #Potassium #Classification ... #Causes
Pragmatic diagnostic algorithm for hypokalemia. ***Typical presentations: • Vomiting: urine Na/Cl > 1.6, low urine
Pragmatic diagnostic algorithm ... urine Na/Cl < 0.7, high ... correcting serum potassium ... angiotensin receptor blockers ... continued in most cases
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