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diagnosis differential bradycardia cardiology high management nephrology pharmacology algorithm classification acidosis adverseeffects anesthesia anesthesiology bradi checklist ddi drugdrug druginduced drugs
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... inhibition (NSAIDs, Beta-Blockers ... MunerMohamed1 #hyperkalemia ... #pharmacology #potassium ... #medications #druginduced
Drugs causing hyperkalemia • Impaired release of renin: NSAIDs, Beta blockers, Cyclosporine, tacrolimus, Diabetes, Elderly •
Drugs causing hyperkalemia ... renin: NSAIDs, Beta ... blockers, Cyclosporine ... Drospirenone #Drugs #hyperkalemia ... #medications #causes
Bradycardia Diagnostic and Management Algorithm CONSIDER ETIOLOGY (not inclusive): - STRUCTURAL: sick sinus, AV block, ischemia,
Hypothyroidism - TOX: beta-blockers ... LIFE THREATENING CAUSES ... & TREATMENT - ... Drugs (beta-blockers ... Electrolytes (hyperkalemia
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
• Recent IV potassium ... • Beta blockers ... Medications 2. ... differential #diagnosis #causes ... #potassium #high
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
• Recent IV potassium ... • Beta blockers ... Medications 2. ... differential #diagnosis #causes ... #potassium #high
Causes of Hyperkalemia - Differential Diagnosis Framework • Cellular Shift: - Exercise
Causes of Hyperkalemia ... hyperosmolality - Medications ... : beta blockers, ... Differential #Diagnosis #Causes ... #potassium #high
Bradycardia - Differential Diagnosis Framework BRADI Mnemonic • BRASH/Hyperkalemia • Reduced oxygen/Glucose/Temp • ACS • Drugs •
surgery • Heart block ... Medications: ... • Beta blockers ... Spondylarthropathies Other causes ... differential #diagnosis #causes
Emergent Hyperkalemia Treatment Algorithm ECG changes, weakness, K+ >6.5 Or renal insufficiency with K >5.5 with cellular
Emergent Hyperkalemia ... bradycardia, AV blocks ... Combo of insulin + beta-agonist ... glucose <100 • Beta-agonist ... Remove potassium
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Etiology: • Medications ... ARBs, NSAIDs, β-blockers ... only if no clear cause ... STOP offending medications ... #potassium #nephrology
Hyperthyroidism Overview Clinical Manifestation of Hyperthyroidism: • Fatigue • Weight loss • Heat intolerance • Depression, nervousness
↑ T3 - Mild hypercalcemia ... ↑ AST/ALT • Treatment ... : - Beta blocker ... : • Beta blockers ... hyperthyroidism #causes
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