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management diagnosis differential gastroenterology hepatology hematology pulmonary cardiology nephrology causes disease guidelines neurology oncology pharmacology clinical ibd rheumatology hyperkalemia primarycare
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Differential Diagnosis Algorithm ... US - Dilated Bile ... Ducts • Common Bile ... Duct Stone • Biliary ... Differential #Diagnosis #Algorithm
Mechanism of Action of Bile Acid Sequestrants Bile Acid Sequestrants → ↓ Hepatic Bile Acid Pool →
Mechanism of Action of Bile ... Sequestrants Bile ... Sequestrants → ↓ Hepatic Bile ... Pool → ↑ Hepatic Bile ... Plasma LDL-C #biliary
Irritable Bowel Syndrome (IBS) Treatment Algorithm IBS-Constipation: • Constipation: Osmotic laxatives • Abdominal pain: Antispasmodics IBS-Diarrhea: • Diarrhea:
Syndrome (IBS) Treatment ... Algorithm IBS-Constipation ... Diarrhea: Loperamide, Bile ... Syndrome #IBS #Treatment ... #Management #Algorithm
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Differential Diagnosis Algorithm ... • US - Normal Bile ... • US - Dilated Bile ... - CBD stone, Biliary ... Transaminitis #Algorithm
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
the liver ALP - Biliary ... tree or bile flow ... abnormality vs bone Bili
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... Extrahepatic - Biliary ... Choledocholithiasis, Biliary ... - Obstruction: Biliary ... differential #diagnosis #algorithm
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Differential Diagnosis Algorithm ... Drugs - Primary biliary ... PSC - Other biliary ... diseases/Bile duct ... Differential #Diagnosis #Algorithm
Indications for ERCP 1. Biliary Tract Diseases: • Biliary obstruction: Choledocholithiasis, Malignant biliary strictures, Benign biliary strictures
Biliary Tract Diseases ... : • Biliary obstruction ... strictures, Benign biliary ... Oddi manometry • Bile ... pancreatitis (treatment
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary ... small intralobular bile ... of intralobular bile ... No extrahepatic biliary ... malignancy #Primary #Biliary
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
genes coding for bile ... Dysfunction - Biliary ... certain drugs, biliary ... , carcinoma of biliary ... external pressure on bile
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