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Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias - Differential ... / unconjugated bilirubin ... Hypersplenism, Infection ... Hemolytic #Anemias #Differential ... Diagnosis #Algorithm #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Internal (RBC) - Infections ... - Unconjugated Bilirubin ... #Hemolysis #Differential ... #Diagnosis #hematology
Bilirubin Metabolism - Pathophysiology • Conjugated Bilirubin • Unconjugated Bilirubin By Dr. Khushboo Gala @LouLectures #Bilirubin #Metabolism #Pathophysiology
Bilirubin Metabolism ... • Conjugated Bilirubin ... • Unconjugated Bilirubin ... LouLectures #Bilirubin ... Pathophysiology #hepatology
Causes of Leukocytosis and Leukopenia - Differential Diagnosis • Eosinophilia (AEC > 500, hypereosinophilia > 1500):
and Leukopenia - Differential ... Connective Tissue, Infections ... Lymphocytosis: Infection ... Leukocytosis #Leukopenia #Differential ... Diagnosis #causes #hematology
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Pancytopenia - Differential ... Infiltration: • Hematologic ... and non-hematologic ... malignancies • Infection ... #Neutropenia #Differential
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Thrombocytosis - Differential ... deficiency) • Infection ... Sepsis • Non-infectious ... Thrombocytosis #Differential ... causes #Platelets #hematology
Biochemistry and Metabolism of Bilirubin Hemolysis → Hemoglobin → Heme → Biliverdin → Unconjugated Bilirubin (a.k.a. "indirect
Metabolism of Bilirubin ... → Unconjugated Bilirubin ... "indirect bilirubin ... and "indirect" bilirubin ... pathophysiology #hepatology
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
• Increased bilirubin ... ) • Impaired bilirubin ... eg, spirochetal infections ... , infectious mononucleosis ... #unconjugated #differential
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Thrombocytosis - Differential ... Myelofibrosis Infectious ... Non malignant hematologic ... states • Non-hematologic ... Thrombocytosis #Differential
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Increased Serum bilirubin ... Anemia #Algorithm #Differential ... Causes #Workup #Hematology
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