208 results
diagnosis differential hematology algorithm anemia causes management hepatology workup pathophysiology nephrology classification hemolysis clinical hyperkalemia microbiology treatment blood liver rheumatology
Laboratory Testing in Hemolytic Anemia Intravascular vs Extravascular Hemolysis Reticulocytes Unconjugated bilirubin LDH Peripheral smear Haptoglobin Urine hemosiderin Urine hemoglobin Carboxyhemoglobin #Hemolytic #Anemia #Laboratory #Testing #workup
Laboratory Testing in Hemolytic ... Extravascular Hemolysis ... Unconjugated bilirubin ... Carboxyhemoglobin #Hemolytic ... diagnosis #hematology #hemolysis
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... of anemia and hemolysis ... / unconjugated bilirubin ... Immune-mediated Hemolysis ... • Autoimmune Hemolytic
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Hemolysis - Diagnostic ... Increased Serum bilirubin ... haptogbbulin #Hemolysis ... #Hemolytic #Anemia
Approach to Neonatal Jaundice Causes of pathologic hyperbilirubinemia can be classified as due to (1) increased bilirubin
(1) increased bilirubin ... pre-hepatic; either hemolytic ... or non-hemolytic ... , (2) impaired bilirubin ... or (3) impaired bilirubin
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Antibody Autoimmune Hemolytic ... reticulocytes • Hemolysis ... haptoglobin ↑ indirect bilirubin ... Antibody #Autoimmune #Hemolytic
Biochemistry and Metabolism of Bilirubin Hemolysis → Hemoglobin → Heme → Biliverdin → Unconjugated Bilirubin (a.k.a. "indirect
Metabolism of Bilirubin ... Hemolysis → Hemoglobin ... → Unconjugated Bilirubin ... "indirect bilirubin ... and "indirect" bilirubin
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
predominantly indirect bilirubin ... • Increased bilirubin ... production (eg, hemolytic ... anemias, hemolytic ... ) • Impaired bilirubin
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
Inherited Non-hemolytic ... without evidence of hemolysis ... birth with serum bilirubin ... associated with bilirubin ... in conjugated bilirubin
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
fold elevation, Bilirubin ... HELLP Syndrome (Hemolysis ... clinical features: Hemolysis ... fold elevation, Bilirubin ... but variable ++, Bilirubin
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
hemorrhage and hemolysis ... intravascular hemolysis ... out an immune hemolytic ... anemia Indirect bilirubin ... the severity of hemolysis
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