96 results
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
weeks • Typical clinical ... fold elevation, Bilirubin ... Disease #Pregnancy #hepatology ... #obstetrics #hepatitis ... #comparison #differential
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
Injury - Ichemic hepatitis ... injury - Viral Hepatitis ... - Autoimmune hepatitis ... Acute #Causes #Differential ... #Hepatology #Diagnosis
Biochemistry and Metabolism of Bilirubin
Hemolysis → Hemoglobin → Heme → Biliverdin → Unconjugated Bilirubin (a.k.a. "indirect
Metabolism of Bilirubin ... → Unconjugated Bilirubin ... "indirect bilirubin ... interchangeably for routine clinical ... pathophysiology #hepatology
Hepatomegaly - Differential Diagnosis Algorithm
Malignant
 • Primary Carcinoma
 • Metastases
 • Lymphoma
 • Leukemia
 • Polycythemia
Hepatomegaly - Differential ... Infectious • Hepatitis ... • Alcoholic Hepatitis ... #Hepatomegaly #Differential ... Algorithm #Causes #Hepatology
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias - Differential ... / unconjugated bilirubin ... Hemolytic #Anemias #Differential ... Diagnosis #Algorithm #hematology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Check Acute viral hepatitis ... Check Acute viral hepatitis ... week • Direct bilirubin ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
Clinical diagnosis ... of Alcoholic Hepatitis ... • Serum total bilirubin ... Possible ischemic hepatitis ... #AH #hepatology
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
Increased Serum bilirubin ... Anemia #Algorithm #Differential ... Causes #Workup #Hematology
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
Clinical Diagnosis ... of Autoimmune Hepatitis ... - Serum total bilirubin ... Possible ischemic hepatitis ... #Diagnosis #Hepatology
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
normal - Ischemic Hepatitis ... - Acute Viral Hepatitis ... , Toxic Hepatitis ... Liver #Injury #hepatology ... transaminitis #differential