99 results
Biochemistry and Metabolism of Bilirubin
Hemolysis → Hemoglobin → Heme → Biliverdin → Unconjugated Bilirubin (a.k.a. "indirect
Metabolism of Bilirubin ... → Unconjugated Bilirubin ... "indirect bilirubin ... interchangeably for routine clinical ... pathophysiology #hepatology
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
normal - Ischemic Hepatitis ... - Acute Viral Hepatitis ... , Toxic Hepatitis ... normal - Hemolysis, NASH ... Liver #Injury #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Check Acute viral hepatitis ... Check Acute viral hepatitis ... week • Direct bilirubin ... disease: > 2 • NASH ... #differential #Hepatology
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
weeks • Typical clinical ... fold elevation, Bilirubin ... fold elevation, Bilirubin ... Disease #Pregnancy #hepatology ... #obstetrics #hepatitis
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
Clinical diagnosis ... of Alcoholic Hepatitis ... • Serum total bilirubin ... Possible ischemic hepatitis ... #AH #hepatology
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
Clinical Diagnosis ... of Autoimmune Hepatitis ... - Serum total bilirubin ... Possible ischemic hepatitis ... #Diagnosis #Hepatology
Monkeypox Vesicular Rash on Skin Exam

#Monkeypox #Rash #Skin #PhysicalExam #clinical #vesicles #dermatology
Monkeypox Vesicular Rash ... #Monkeypox #Rash ... #PhysicalExam #clinical ... #vesicles #dermatology
Syphilis Rash on Palms and Soles

#Syphilis #Rash #Palms #Soles #clinical #dermatology #skin #secondary #PhysicalExam
Syphilis Rash on ... #Syphilis #Rash ... #Palms #Soles #clinical ... #dermatology #skin
DRESS Syndrome vs SJS/TEN
DRESS
 • Latency: 2-8 weeks
 • Rash: Morbilliform
 • Mucosal involvement: 50% have
: 2-8 weeks • Rash ... leukocytosis • Hepatitis ... : 4-28 days • Rash ... Lymphopenia • Hepatitis ... comparison #table #dermatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
week • Direct bilirubin ... disease: > 2 • NASH ... Chronic viral hepatitis ... Elevation: • Bilirubin ... diagnosis #algorithm #hepatology