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diagnosis treatment cardiology erythematosus lupus systemic cardiomyopathy endocarditis hemophagocytic hlh lymphohistiocytosis peripartum sjogrens stills syndrome
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's Disease ... hepatitis • Pulmonary ... Prunelle Getten #AdultOnset ... #diagnosis #management ... #treatment #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Erythematosus - Summary ... • Specific for SLE ... #Summary #diagnosis ... #rheumatology # ... management
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Diagnosis and Management ... Summary • Epidemiology ... Usual therapeutic management ... : Chronic disease ... #Summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
: SLE+++, Adult-onset ... Still disease, ... Lymphohistiocytosis #diagnosis #management ... #treatment #summary ... #rheumatology
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
Endocarditis Summary ... Congenital heart disease ... • Autoimmune (SLE ... Cerebral > Splenic, pulmonary ... Endocarditis #diagnosis #management
Peripartum Cardiomyopathy - Summary 1. Definition • Towards the end of pregnancy to 5 months postpartum
Cardiomyopathy - Summary ... Valvular heart disease ... Congenital heart disease ... cardiomyopathy • Pulmonary ... orthopnea, PND, LE
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... : • 10%-15% Pulmonary ... , INC risk PE, Pulmonary ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
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