585 results
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
of Pregnancy (AFLP ... Thomas DeLoughery @Bloodman ... TTPHUS #HELLP #AFLP ... #obstetrics #hematology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
(ALT or AST > ALP ... Wilsons, Pregnancy - AFLP ... Cholestatic Pattern (ALP ... Algorithm #diagnosis #hepatology
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Tom DeLoughery @Bloodman ... TTPHUS #HELLP #AFLP ... Obstetrics #OBGyn #Hematology
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
for the liver ALP ... Transaminase, ALP ... / ULN ALT) / (ALP ... / ULN ALP) ... Transaminitis #diagnosis #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Alkaline Phosphatase (ALP ... Diagnosis Algorithm ALP ... - Increased ALP ... #Phosphatase #ALP ... Diagnosis #Algorithm #hepatology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... iMedEducation #AFLP ... Liver #Pregnancy #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
• Pregnancy - AFLP ... Others #LFTs #Hepatology
Thalassemias on Hemoglobin Electrophoresis
Beta-Thalassemia:
 • Major
 • Intermediate
 • Trait
Alpha Thalassemia:
 • Trait-1 (α α/ α-)
Thomas DeLoughery @Bloodman ... interpretation #diagnosis #hematology
Methylmalonic Acid and Homocysteine Levels in Vitamin B12 and Folate Deficiency
 • B12 Deficiency: MMA elevated,
Thomas DeLoughery @Bloodman ... VitaminB12 #diagnosis #hematology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
(Alk phos/ULN ALP ... • AST/ALT > ALP ... Cholestasis • ALP ... disease • If ALP ... #differential #Hepatology