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management risk stratification differential endocarditis febrile fungal infant lp pediatrics peds stepbystep table betadglucan biomarkers cardiology galactomannan microbiology acute bloodcultures
Fungal Biomarkers: Comparing Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi •
Beta-D-Glucan and Aspergillus ... Polysaccharide cell wall component ... Spec ~77-96% Aspergillus ... Galactomannan #diagnosis ... #comparison #microbiology
Suspected catheter-related bloodstream infection - Management Algorithm • Temperature 37.8 C • Rigors
infection - Management Algorithm ... • Persistent fever ... • Persistent fever ... infection #Management #Algorithm ... #CRBSI #diagnosis
“Step by Step” – the new kid on the block – aims to risk stratify this
for each of the components ... of the algorithm ... an infant with fever ... CRP < 20 mg/L #Diagnosis ... #LP #Antibiotics
My Patient with Infective Endocarditis (IE) Has Negative Blood Cultures - Did they receive antibiotics prior
Did they receive antibiotics ... Decreased yield due to antibiotic ... Fungal (Histoplasma/Aspergillus ... BloodCultures #Diagnosis ... #Management #Algorithm
Validation of the Step-By-Step Approach to Febrile Infants #Diagnosis #Management #Pediatrics #Peds #Febrile #Infant #StepByStep #Algorithm #LP
Febrile Infants #Diagnosis ... Infant #StepByStep #Algorithm ... #LP #Antibiotics ... Stratification #Fever
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
Beta-D-Glucan and Aspergillus ... Polysaccharide cell wall component ... post-2010 almost never ... Galactomannan #diagnosis ... #comparison
Approach to Eosinophilic Lung Diseases • Acute Eosinophilic Pneumonia (< 1 wk) - ~30yo, M; Recent
initiation of smoking; Fever ... brown sputum, fever ... Variable) - NSAIDs, antibiotics ... #differential #diagnosis ... #comparison #table
Algorithm for the Evaluation of Acute Diarrhea (< 7 days) Are the following present? 1.
Algorithm for the ... hospitalization or antibiotics ... Consider empiric antibiotic ... Bloody diarrhea, fever ... #workup #diagnosis
Important Fungal Stains Mycology Lab: • Calcofluor white - Fluorochrome that binds glucans and chitin in fungal
exceptions are Aspergillus ... polysaccharide component ... microscopy #staining #diagnosis ... fungi #fungus #comparison
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
Tropheryma Whipplei • Aspergillus ... night sweats, fever ... Differential Diagnosis ... • IV Antibiotics ... Persistent bacteremia/fevers
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