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diagnosis differential hematology hyperkalemia nephrology high management potassium reactions anemia blood deficiency folate glomerular intravascular nephrotic nutrition product testing workup
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Causes of False ... Content • RBC Transfusions ... blood loss • Hemolytic ... Effect • RBC Transfusions ... #Decrease #Diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... HUS) • Other: Transfusion ... reaction, Paroxysmal ... implicated) - Transfusion ... Extravascular #Causes
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Transfusion Thresholds ... Transfusion Reaction ... Transfusion Reaction ... Transfusion Reaction ... Causes purpura &
Folate Deficiency - Causes of Decreased Folic Acid ↓ Intake: Diet, Age, Alcohol ↑ Demand: Pregnancy, Infancy, Hemolysis,
Folate Deficiency - Causes ... of Decreased Folic ... Pregnancy, Infancy, Hemolysis ... Enteritis, Jejunal resection ... Folate #Deficiency #FolicAcid
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Transfusion Reaction ... Transfusion Reaction ... Transfusion Reaction ... Causes purpura & ... TRALI): Leading cause
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
venipuncture • Hemolysis ... - Transfusion ... reaction - Tumor ... Blood transfusion ... differential #diagnosis #causes
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
venipuncture • Hemolysis ... - Transfusion ... reaction - Tumor ... Blood transfusion ... differential #diagnosis #causes
Causes of HyperKalemia - Differential Diagnosis Increased extracellular K+: • Tissue injury • Hemolysis • Rhabdomyolysis •
Causes of HyperKalemia ... Tissue injury • Hemolysis ... intake • Blood transfusion ... of injection Decreased ... Differential #Diagnosis #Causes
Jaundice - Differential Diagnosis Algorithm Pre-Hepatic - Unconjugated Hyperbilirubinemia Increased Production • Hemolysis • Ineffective Erythropoiesis • Hematoma Decreased
Hyperbilirubinemia Increased Production ... • Hemolysis ... • Hematoma Decreased ... Rifampin) Decreased ... Diagnosis #Algorithm #Causes
Etiologies of Folate Deficiency • Decreased dietary intake - uncommon in this era • Increased requirements
Deficiency • Decreased ... pregnant have hemolytic ... folate that can cause ... anticonvulsants lead to increase ... Folate #deficiency #FolicAcid
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