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diagnosis management blood differential product reactions coagulation dic disseminated dm2 elevation false hba1c hgba1c hyperkalemia increase intravascular reduction thromboticthrombocytopenicpurpura transfusions
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Causes of False ... • Asplenia Laboratory ... Content • RBC Transfusions ... blood loss • Hemolytic ... HbA1c #HgbA1c #Laboratory
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Transfusion Thresholds ... Causes purpura & ... TRALI): Leading cause ... products contain potassium ... diagnosis #management #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... TRALI): Leading cause ... products contain potassium ... more likely to cause ... diagnosis #management #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... Mild-to-moderate decrease ... in most cases; ... Platelet count - Decreased ... Diagnosis #Workup #Hematology
Causes of Hyperkalemia Pseudohyperkalemia - Tourniquet use - Hemolysis (in vitro) - Leukocytosis - Thrombocytosis Intra- to extracellular
Causes of Hyperkalemia ... Tourniquet use - Hemolysis ... drugs - Transfusion ... aged blood - Hemolysis ... tissue necrosis Decreased
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
incompatible blood transfusion ... venipuncture sites Laboratory ... Treat primary cause ... hydration • RBC transfusion ... treatment #management #hematology
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