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Subtrochanteric Femur Fracture: Pathogenesis and clinical findings • Subtrochanteric region spans 5 cm distally from the
fractures in elderly Causes ... Bisphosphonate suppresses bone ... damage weakens the bone ... #differential #causes ... #pathophysiology
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Weakness, Incr CK • Bone ... Myopathy (Also caused ... Complications #pathophysiology
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Abnormal Osteoclasts cause ... excessive bone ... Skull expansion causes ... middle ear bones causes ... PagetsDisease #pathophysiology
Acquired Disorders of Reduced Bone Strength: Pathogenesis • Hyperparathyroidism • Vitamin D deficiency • Malabsorption syndromes
Disorders of Reduced Bone ... Diabetes • Other causes ... of bone mineralization ... #BoneStrength #pathophysiology
The Inhibited Pathway caused by N2O, leading to a decrease in the active form of Vitamin
Inhibited Pathway caused ... use of N2O can cause ... anemia includes bone ... #Pathophysiology
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
synthesized in: liver, bone ... Most cases diagnosed ... : Inhibitor of bone ... collection with EDTA Pathophysiology ... Phosphatase: • Other causes
Avascular Necrosis: Pathogenesis and Clinical Findings • Physical Trauma (esp. to the scaphoid bone with damage
to the scaphoid bone ... vessels that perfuse bone ... ) • Multiple causes ... Hypoxic death of bone ... AvascularNecrosis #pathophysiology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... , Biological + Bone ... /ml, ↑ LDH • Bone ... Drugs, Unknown cause ... 100 mg/m2) : in case
Diabetic Foot: Pathogenesis and clinical findings • Polyol Pathway - Excess glucose enters Polyol pathway ->
Glycosylation - AGE cause ... - Infection of bone ... formation, and bone ... #DiabeticFoot #pathophysiology
Fracture Healing (and disruptors of this process) Inflammatory Stage (0-7d) • Fracture disrupts local blood vessels ->
osteoblasts forms bony ... Osteoclast-osteoblast coupled bone ... Fluoroquinolones - Causes ... from GI tract, bone ... #msk #Staging #pathophysiology
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