28 results
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Hypersensitivity ... - Local and systemic ... Complement activation ... lupus erythematosus ... #Types #Classification
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Criteria for Systemic ... anticoagulant • Complement ... #EULARACR #Classification ... Criteria #SLE #Systemic
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
table of types of hypersensitivity ... Allergen-specific lgE causes ... glomerulonephritis, Systemic ... lupus erythematosus ... allergy #table #classification
Hypersensitivity: Summary
Type I Hypersensitivity:
 • Immunological Mediator: lgE
 • Immunological Target: Allergen Molecules
 • Ex: Antibiotic
Hypersensitivity ... Summary Type I Hypersensitivity ... complexes • Ex: Systemic ... Lupus Erythematosus ... Reactions #Types #Classification
Causes of Interstitial Lung Disease - Differential Diagnosis Algorithm
Idiopathic Interstitial Pneumonia
 • (UIP) Usual Interstitial Pneumonia
Causes of Interstitial ... Differential Diagnosis Algorithm ... Rheumatoid Arthritis, Systemic ... Lupus and Scleroderma ... Diseases #ILD #Causes
Type III Hypersensitivity: Pathogenesis and clinical findings
Definition: Small antigen-antibody complexes (produced from normal immune response to
Type III Hypersensitivity ... self-antigens are the cause ... : • Systemic Lupus ... antigens are the cause
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
Classification of ... central nervous system ... vasculitis - hypersensitivity ... disease - systemic ... lupus erythematosus
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... , oral ulcers, Lupus ... Positive in 60-80% of cases ... 80% - Low complement ... #Systemic #Erythematosus
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... glomerulonephritis (>90%) S - Systemic ... Lupus Erythematosus ... Hypocomplementemia #Low #Complement
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... Post-strep GN, Lupus ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm