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diagnosis differential rheumatology alopecia causes classification dermatology hairloss ana antinuclear erythematosus sle vasculitis arthritis criteria disease disorders eularacr focal glomerulonephritis
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... • Nucleolar: Diffuse ... #Antinuclear #Antibodies ... #ANA #patterns ... #rheumatology #diagnosis
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... • Nucleolar: Diffuse ... #Antinuclear #Antibodies ... #rheumatology #diagnosis
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Classification Criteria for Systemic ... pericarditis • Hematologic ... anticoagulant • Complement ... Highly specific antibodies ... Criteria #SLE #Systemic
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Differential Diagnosis Algorithm ... Reactive: - Systemic ... Lupus Erythematosus ... #Causes #Hematology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... Post-strep GN, Lupus ... Purpura Anti-GBM antibodies ... differential #diagnosis #algorithm ... #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low complements ... pneumonitis • Diffuse ... enteropathy, and diffuse ... , Complement levels
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm DIFFUSE Scarring - Irreversible-biopsy required • Lupus
Differential Diagnosis Algorithm ... Irreversible-biopsy required • Lupus ... planopilaris Pattern ... • Discoid lupus ... Differential #Diagnosis #Algorithm
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
site in lymphatic system ... with lymphatic system ... lymphadenopathy more diffuse ... involvement, irregular pattern ... pathophysiology #Hematology
Allopecia - Differential Diagnosis Framework for Hair Loss Localized / Focal Hair Loss Pattern: • Scarring Alopecia:
Disease: Discoid lupus ... Traction alopecia Diffuse ... Scarring Alopecia: Lupus ... Vitamin D levels Systemic ... Differential #Diagnosis #dermatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
lupus erythematosus ... - (C-ANCA) pattern ... : antibodies directed ... - (P-ANCA) pattern ... against MPO • Complement
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