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diagnosis differential rheumatology classification vasculitis acute aki causes cryoglobulinemia cryoglobulins erythematosus hematology kidneyinjury lymphomas lymphoproliferative mimics nephrology nonhodgkin pathophysiology pulmonary
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Rapidly Progressive ... staining): • Low Complement ... Post-strep GN, Lupus ... RPGN #Rapidly #Progressive ... differential #diagnosis #algorithm
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
Diagnosis Framework Diffuse ... hemorrhage + rapidly progressive ... glomerulonephritis ... anti-GBM) 10%: - Low Complement ... Vasculitis - Normal Complement
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm Acute Kidney Injury (AKI) - Acute increase
Differential Diagnosis Algorithm ... Malignancy Rapidly Progressive ... Glomerulonephritis ... IgA, post-strep, lupus ... legionella) • Immune (lupus
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... ) • Endocrine disorders ... pneumonitis • Diffuse ... enteropathy, and diffuse ... RNP antibodies, Complement
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Skin ulcers - Glomerulonephritis ... hematological disorders ... to Autoimmune Disorders ... • Low serum C4 complement ... (e.g. systemic lupus
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Lymphoproliferative Disorders ... Differential Diagnosis Algorithm ... system (node) with progression ... lymphadenopathy more diffuse ... #differential #algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
proteinuria, rapidly progressing ... - Necrotizing glomerulonephritis ... inflammation Others: • Lupus ... such as systemic lupus ... against MPO • Complement
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