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diagnosis differential rheumatology vasculitis arthritis causes cryoglobulinemia cryoglobulins disease erythematosus gammopathy glomerulonephritis hematology high hyperkalemia hypoxemia hypoxia laboratory lymphomas lymphoproliferative
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Rapidly Progressive ... staining): • Low Complement ... Post-strep GN, Lupus ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Skin Disease Classification ... pneumonitis • Diffuse ... enteropathy, and diffuse ... RNP antibodies, Complement
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Lymphoproliferative Disorders ... Differential Diagnosis Algorithm ... lymphadenopathy more diffuse ... correlated with rapid ... #Classification
Hypoxemia / Hypoxia - Rapid Response Management Algorithm Stridor - Upper airway pathology: • Anaphylaxis • Foreign
Hypoxemia / Hypoxia - Rapid ... Response Management Algorithm ... pathology: • Blood: diffuse ... Neuromuscular disorders ... #rapid #pulmonary
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
hematological disorders ... to Autoimmune Disorders ... • Low serum C4 complement ... (e.g. systemic lupus ... diagnosis #types #classification
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
, proteinuria, rapidly ... inflammation Others: • Lupus ... such as systemic lupus ... against MPO • Complement ... #rheumatology #classification
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
joint • Systemic lupus ... (3) Rises more rapidly ... Screening Tests for Diffuse ... metabolic or endocrine disorders ... Additional Tests for Diffuse
Causes of Hyperkalemia l. Pseudohyperkalemia A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis B.
neuromuscular injury, disuse ... Rapid tumor lysis ... diseases: syßtemic lupus ... High #Potassium #Classification
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
or plasma cell disorder ... proteinuria with rapid ... guide subtype classification ... tubulopathy) - Complement
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