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diagnosis differential dermatology causes rheumatology management skin sle vesicular vesiculobullous alopecia comparison disorders druginduced erythematosus hairloss hypopigmentation skinrash systemic vasculitis
Algorithm for Diagnosis of the Vesiculobullous Rash Febrile, Diffuse Distribution: - Varicella, Smallpox, Disseminated, Gonococcal,
Algorithm for Diagnosis ... Vesiculobullous Rash ... Febrile, Diffuse ... #Algorithm #Diagnosis ... #Dermatology #Skin
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Malignancy (e.g. hematologic ... pneumonitis • Diffuse ... enteropathy, and diffuse ... RNP antibodies, Complement
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Manifestations: Malar rash ... , oral ulcers, Lupus ... 80% - Low complement ... Management #Summary #rheumatology
Vesiculobullous Rashes - THE ALGORITHMIC APPROACH Vesiculobullous rashes provoke significant angst in many physicians (Figure 5, page
Vesiculobullous Rashes - THE ALGORITHMIC ... distribution is diffuse ... Patients with a diffuse ... #Diagnosis #Dermatology ... #Algorithm #Differential
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Differential Diagnosis Algorithm ... • Systemic Lupus ... Hodgkin's Lymphoma #Diffuse ... #Causes #Hematology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... Post-strep GN, Lupus ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm ... #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
NPSLE rare, Malar rash ... 90% - Low complement ... Manifestations: Malar rash ... 80% - Low complement ... comparison #table #rheumatology
Skin Hypopigmentation - Differential Diagnosis Algorithm Diffuse Congenital - Generalized hypopigmentation of hair, eyes, skin • Phenylketonuria
Differential Diagnosis Algorithm ... Diffuse Congenital ... • Piebaldism Diffuse ... sclerosis (white "ash ... disorders #skin #dermatology
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
muscle weakness, rash ... Anti-retrovirals, Gemcitabine Lupus ... Myopathy • Diffuse ... uncommon 5-15% of lupus ... diagnosis #comparison #rheumatology
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm DIFFUSE Scarring - Irreversible-biopsy required • Lupus
Differential Diagnosis Algorithm ... Irreversible-biopsy required • Lupus ... • Discoid lupus ... HairLoss #Alopecia #dermatology ... Differential #Diagnosis #Algorithm
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