19 results
diagnosis differential causes classification hematology nephrology pulmonary renal rheumatology types workup allergy anemia bruising glomerular hemolytic hypersensitivity management nephrotic reactions
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... Idiopathic • Normal Complement ... involvement: Anti-GBM Disease ... #Vasculitis #differential ... #diagnosis #algorithm
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
rapidly progressive glomerulonephritis ... - Anti-GBM Disease ... anti-GBM) 10%: - Low Complement ... - Normal Complement ... , Behcet's Disease
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Necrotizing glomerulonephritis ... , pauci-immune glomerulonephritis ... • Glomerulonephritis ... arthritis. (± glomerulonephritis ... against MPO • Complement
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
alveolar hemorrhage + Glomerulonephritis ... ANCA-positive vasculitis ... ANCA-negative vasculitis ... IgA-associated vasculitis ... testing: anti-ANCA
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Differential Diagnosis Algorithm ... • Steroids • Vasculitis ... Coagulation #Bleeding ... Differential #Diagnosis #Algorithm
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
immune system, leading ... Skin ulcers - Glomerulonephritis ... • Autoimmune diseases ... • Low serum C4 complement ... • Vasculitis
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... Consider sickle cell disease ... cardiac valve, vasculitis ... Differential #Diagnosis #Algorithm ... workup #hematology #testing
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... for glomerular disease ... or alternative complement ... for ANCA-related vasculitis ... workup #diagnosis #glomerulonephritis
Guide to Acute Kidney Injury (AKI) What to ask/look for: - HPI, PMH, full ROS
- Pre-renal disease ... related) - Glomerulonephritis ... or vasculitis — ... Nephrology #Diagnosis #Algorithm
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
cellular antigen, leading ... to complement activation ... during hemolytic disease ... Complement activation ... Post-streptococcal glomerulonephritis
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