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diagnosis differential rheumatology hematology lupus testing classification erythematosus glomerular glomerulonephritis management nephrology nephrotic renal systemic table anemia c3 c4 comparison
Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
Effect of Selected Diseases ... on Complement Levels ... - C3, C4 • SLE ... C3 ↓ C4 ↓↓ • Cryo ... ThePeanutKidney #Complement
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
- Anti-GBM Disease ... anti-GBM) 10%: - Low Complement ... Levels: SLE, Cryoglobulinemic ... - Normal Complement ... , Behcet's Disease
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
(Granulomatous disease ... atherosclerotic disease ... most important diseases ... against MPO • Complement ... , and SLE) • Urinalysis
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... Idiopathic • Normal Complement ... involvement: Anti-GBM Disease ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Erythematosus (SLE ... are evocative of SLE ... • Immunologic Workup ... 80% - Low complement ... Evolution: Chronic disease
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... ): SS, SC, SE, Sβ ... cardiac valve, vasculitis ... Differential #Diagnosis #Algorithm ... #workup #hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... 90% - Low complement ... • Immunologic Workup ... 80% - Low complement ... Evolution: Chronic disease
Hyperthyroidism (low TSH, High T4/T3) - Diagnostic Algorithm Radioactive iodine scan – get if concern for nodular
) - Diagnostic Algorithm ... affects diagnostic workup ... management options (see ... Hyperthyroid #Diagnosis #Algorithm ... #Workup #Endocrinology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... ANCA-associated vasculitis ... • Mesenteric vasculitis ... inflammation Cutaneous Vasculitis ... RNP antibodies, Complement
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... : - 10% SLE or ... • Low serum C4 complement ... • Vasculitis ... erythematosus (SLE
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