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lupus classification management anca antibody autoimmune causes conditions extrarticular hypertension igg4 joint mimickers myopathy myositis pain phenotypes phtn related signs
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic Diseases ... tissue disease ... #Antibodies #ANA ... #patterns #rheumatology ... #diagnosis #differential
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... (SLE), Systemic ... , Interstitial Pulmonary ... #patterns #rheumatology ... #diagnosis #differential
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
connective tissue disease ... 90% • Anti-GBM disease ... #antibodies #diagnosis ... #rheumatology # ... diseases
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Decade Skin Disease ... Diagnosis: • ANCA-associated ... diseases (i.e. ... #Diagnosis #Rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... auto-immune, Infectious diseases ... sclerosis, Still's disease ... #Diagnosis #autoantibodies ... #rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... Association with disease ... with auto-immune diseases ... #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
disease, and ocular ... Diagnosis: Systemic ... ) pattern: antibodies ... differential #diagnosis ... #rheumatology #
Clinical Classification of Pulmonary Hypertension 1. Pulmonary arterial hypertension from pulmonary vasculopathy Idiopathic pulmonary arterial hypertension Heritable gene mutations
Clinical Classification ... due to lung disease ... disease Interstitial ... lung disease Other ... pulmonary disease
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
multisystemic disease ... associated with other diseases ... demyelinating disease ... Tracheobronchial disease ... Sjogrens #Syndrome #Rheumatology
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... Clinical history ... (antinuclear antibodies ... IgG4 #Related #Disease ... workup #treatment #rheumatology
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