12 results
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... Auto-Antibodies ... Diagnosis and Lupus ... #Diagnosis #autoantibodies ... #rheumatology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
(SLE), Systemic ... : Lupus (SLE), Systemic ... , Interstitial Pulmonary ... #rheumatology #diagnosis ... #differential
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Classification: ... Diagnosis: • ANCA-associated ... Kidney disease common ... #Diagnosis #Rheumatology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... lung disease (GLILD ... Chest CT: • Ground-glass ... hemolytic anemia) • Systemic ... #immunology #hematology
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... overlap syndromes ... #erythematosus ... #diagnosis #rheumatology
Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Interstitial lung ... , SLEPulmonary ... syndrome - SLE ... #joint #pain #differential ... #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Diagnosis: Systemic ... purpura: strong sign ... SLE) • Urinalysis ... #diagnosis #rheumatology ... #classification
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... salivary ducts Clinical ... : • 10%-15% Pulmonary ... MALT Lymphoma • Lung ... #Rheumatology #
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Epidemiology: • Most common ... Orange or Hep C Clinical ... weeks without infection ... Physical Exam/Signs ... workup #oncology #hematology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Diagnosis: • Systemic ... , such as SLE, atherosclerotic ... purpura: Strong sign ... Nodosa: • PAN most commonly ... #Diagnosis #Rheumatology