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differential patterns antibody testing vasculitis anca antineutrophil classification cytoplasmic dermatology diseases disorders glomerulonephritis hematology management petechiae petechial physicalexam progressive rapidly
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
scleroderma (SSc) • Nucleolar ... @AnnKumfer #Antinuclear ... #Antibodies #ANA ... #patterns #rheumatology ... #diagnosis #differential
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... (ANA) ANA or Anti-NucIear ... , Interstitial Pulmonary ... #Antibodies #ANA ... #patterns #rheumatology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... ARUPConsult @ARUPLabs #ANA ... #Antinuclear #Antibody ... #differential #diagnosis ... #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
and Platelet Disorders ... - Differential Diagnosis ... (e.g., SLE), anti-phospholipid ... antibodies, Quantitative ... #hematology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... in drug-induced SLE ... #Antinuclear #Antibody ... #antibodies #diagnosis ... #rheumatology #
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
Antinuclear Antibody ... Homogeneous pattern: • SLE ... pattern: • SjS, SLE ... #differential #diagnosis ... #rheumatology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Thrombocytopenia - Abnormal platelet ... Measurement of antinuclear ... • Abdominal ultrasound ... #Algorithm #Causes
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Purpura Anti-GBM antibodies ... With associated pulmonary ... #differential #diagnosis ... #algorithm #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... ab • RF • Antinuclear ... Hypocomplementemia • Can cause ... , INC risk PE, Pulmonary ... Sjogrens #Syndrome #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often causes arthritis ... LFT • ESR • ANA ... ) pattern: antibodies ... SLE) • Urinalysis ... #rheumatology #
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