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differential vasculitis antibodies classification management nuclear antineutrophil arthritis cryoglobulinemia cryoglobulins cytoplasmic disorders laboratory platelet progressive prs rapidly renal rheumatic rheumatoid
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... Antibody) and ANCA ... #Antinuclear #Antibody ... #rheumatology # ... diseases
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antibody refers ... : The ANA patterns ... , Interstitial Pulmonary ... #patterns #rheumatology ... #diagnosis #differential
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... ARUPConsult @ARUPLabs #ANA ... #Antinuclear #Antibody ... #differential #diagnosis ... #rheumatology
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
Antinuclear Antibody ... pattern: • SLE ... ARUPConsult @ARUPLabs #ANA ... #Antinuclear #Antibody ... #diagnosis #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
involvement: Anti-GBM Disease ... (C-ANCA): GPA > ... > eGPA • MPO-ANCA ... (P-ANCA): eGPA, ... #algorithm #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
disease, and ocular ... (Granulomatous disease ... atherosclerotic disease ... LFT • ESR • ANA ... #rheumatology #
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Studies in Rheumatic Diseases ... antibody (ANA) test ... #diagnosis #testing ... #Rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
and Workup History ... PT, aPTT(liver disease ... function test, ANA ... bypass), LFT (liver disease ... #hematology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Summary Autoimmune ANCA ... life-threatening diseases ... Inflammatory eye disease ... Auto-antibodies: ANCA ... • IF staining patterns
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Systemic rheumatic diseases ... disease, drug reactions ... most important diseases ... disease, and ocular ... #Rheumatology
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