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differential classification antineutrophil aortitis conditions cryoglobulinemia cryoglobulins erythematosus joint laboratory patterns rheumatic rheumatoid syndrome testing types workup
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... ) • Systemic lupus ... Vasculitis: • ... Renal-limited vasculitis ... #antibodies #diagnosis
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... (SLE), Sjogren's ... (SLE), Systemic ... : Lupus (SLE), Systemic ... #Antibodies #ANA
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Non-Infectious Aortitis: • Vasculitides ... ), ANCA associated ... vasculitis (rare ... ) • Rheumatic Diseases ... : IgG4-Related Disease
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often causes arthritis ... disease, and ocular ... Vasculitis: + MPO-ANCA ... diseases, such ... as systemic lupus
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Antiphospholipid-antibody ... Vasculitis (e.g. ... #Extrarticular ... #differential #diagnosis ... #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... : • ANCA-associated ... vasculitis, rheumatoid ... • Mesenteric vasculitis ... inflammation Cutaneous Vasculitis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis: • Systemic ... rheumatic diseases ... most important diseases ... often causes arthritis ... disease, and ocular
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... DDX: • ANCA (Antineutrophil ... • Vasculitis ... arthritis, Sjögren's ... #vasculitis
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
multisystemic disease ... demyelinating disease ... ) • Cutaneous vasculitis ... Vasculitis: • ... #Diagnosis #Management
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Studies in Rheumatic Diseases ... (SLE) - Antinuclear ... antibody (ANA) ... connective-tissue disease ... #Rheumatic #Disease
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