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differential antibody antineutrophil aortitis cryoglobulinemia erythematosus extrarticular laboratory management patterns rheumatoid syndrome testing types workup
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Rheumatic Diseases ... (SLE), Sjogren's ... : Lupus (SLE), Systemic ... #Antibodies #ANA
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... ) • Systemic lupus ... Vasculitis: • ... Renal-limited vasculitis ... #antibodies #diagnosis
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Non-Infectious Aortitis: • Vasculitides ... ), ANCA associated ... vasculitis (rare ... ) • Rheumatic Diseases ... Systemic lupus
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often causes arthritis ... disease, and ocular ... Vasculitis: + MPO-ANCA ... : Systemic rheumatic ... as systemic lupus
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
IBD, Whipple's disease ... , Lyme disease, ... Vasculitis (e.g. ... #joint #pain #differential ... #diagnosis #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... DDX: • ANCA (Antineutrophil ... (SLE), rheumatoid ... arthritis, Sjögren's ... vasculitis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... vasculitis, rheumatoid ... : • Joint pain ... • Mesenteric vasculitis ... inflammation Cutaneous Vasculitis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis: • Systemic ... rheumatic diseases ... most important diseases ... often causes arthritis ... disease, and ocular
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
multisystemic disease ... associated with other diseases ... demyelinating disease ... ) • Cutaneous vasculitis ... Vasculitis: •
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Diseases • Septic ... • Systemic lupus ... exclude inflammatory disease ... connective-tissue disease ... #Disease #Rheumatoid
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