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differential ana classification patterns antibody antineutrophil aortitis conditions cryoglobulinemia erythematosus joint laboratory management rheumatic syndrome testing types vasculitides workup
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... (SLE), Sjogren's ... • Rheumatic Diseases ... : Lupus (SLE), Systemic ... Arthritis, Sjögren
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Diseases: • Homogeneous ... connective tissue disease ... (SLE), Sjogren's ... (SLE), Systemic ... #Antibodies #ANA
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
) • Systemic lupus ... connective tissue disease ... 90% • Anti-GBM disease ... #antibodies #diagnosis ... diseases
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
polychondritis, Behcet's Disease ... ), ANCA associated ... ) • Rheumatic Diseases ... : IgG4-Related Disease ... Systemic lupus
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... lupus erythematosus ... (SLE), rheumatoid ... arthritis, Sjögren's ... classification #rheumatology
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
, Lyme disease, ... Vasculitis (e.g. ... #Extrarticular ... #differential #diagnosis ... #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
disease, and ocular ... • Kawasaki Disease ... : Systemic rheumatic ... diseases, such ... as systemic lupus
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... vasculitis, rheumatoid ... Still disease, ... diseases (i.e. ... #Systemic #Lupus
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
: • Systemic rheumatic ... diseases, such ... disease, drug reactions ... most important diseases ... (GRANULOMATOUS DISEASE
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
multisystemic disease ... associated with other diseases ... demyelinating disease ... peripheral Thyroid Disease ... Tracheobronchial disease
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