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Clinical Manifestations of Systemic Lupus Erythematosus (SLE) #Systemic #Lupus #Erythematosus #SLE #Manifestations #Signs #Symptoms #Rheumatology #Diagnosis
Clinical Manifestations ... of Systemic Lupus ... ) #Systemic #Lupus ... Manifestations #Signs
Approach to managing Glomerulonephritis (GN) in children. ANCA, antineutrophil cytoplasmic antibodies; c-ANCA, cytoplasmic antineutrophil cytoplasmic antibodies;
ANCA, antineutrophil ... antibodies; c-ANCA ... hypertension; p-ANCA ... SLE, systemic lupus
Glomerulonephritis - Differential Diagnosis Framework ANCA: • C-ANCA: GPA (Wegener's) • P-ANCA: Microscopic Polyangiitis, Eosinophilic GPA (Churg
Diagnosis Framework ANCA ... : • C-ANCA: GPA ... Wegener's) • P-ANCA ... Membranoproliferative • ↓C4: Lupus
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Rheumatology • Lupus ... glycoprotein I (ß2GP), Lupus ... Polymerase Ill • ANCA ... Vasculitis: P-ANCA ... perinuclear), C-ANCA
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Post-strep GN, Lupus ... Negative IF): • PR3-ANCA ... (C-ANCA): GPA > ... > eGPA • MPO-ANCA ... (P-ANCA): eGPA,
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antibody) and ANCA ... ) • Systemic lupus ... 80-90%) > MPO - ANCA ... MPO: 75-80% - ANCA ... disease - MPO>PR3 - ANCA
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... to 1:1 F:M • Clinical ... - Rare - pANCA ... 40, F:M 9:1 • Clinical ... 50-60% - pANCA
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... 40, F:M 9:1 • Clinical ... , oral ulcers, Lupus ... 50-60% - pANCA ... Lupusreference #SLE #lupus
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... #Systemic #Lupus ... pathophysiology #signs
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Associated - ANCA ... Granulomas - ANCA ... inflammation Others: • Lupus ... such as systemic lupus ... purpura: strong sign
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