59 results
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... Manifestations • Immune Complex ... #Systemic #Lupus ... Complications #pathophysiology
Complete AV Canal Defect on Echocardiogram

Among pts with Pulmonary Arterial Hypertension, those with Eisenmenger syndrome have
Complete AV Canal ... Complete AV canal ... Ivan_Echocardio #CAVCD ... #Complete #AVCanal
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Lead aVR on EKG
Lead aVR can provide some unique insight into 5 different conditions:

 - Acute
AVRT in narrow complex ... aberrancy in wide complex ... #AVR #Utility #ALiEM
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... antibiody -> Immune Complex ... > Incr Immune Complex ... Vasculitis #HUV #Pathophysiology
Type II Hypersensitivity: Pathogenesis and clinical findings
Definition: When antigens bind to the body's cell surfaces, forming
antigen-surface complex ... antigen-surface complex ... against these complexes ... or the entire complex ... Allergy #Immunology #pathophysiology
Mechanical Bowel Obstruction and Ileus - Pathogenesis and Clinical Findings
Ileus: Functional bowel "blockage", no peristalsis
Mechanical Obstruction:
of bowel lumen Complete ... Incomplete obstructions ... bowel-movements (suggests complete ... light-switch pain") with complete ... obstruction #sbo #ileus #pathophysiology
Type III Hypersensitivity: Pathogenesis and clinical findings
Definition: Small antigen-antibody complexes (produced from normal immune response to
antigen-antibody complexes ... : • Systemic Lupus ... Allergy #Immunology #pathophysiology
Glomerulonephritis - Differential Diagnosis Framework
ANCA:
 • C-ANCA: GPA (Wegener's)
 • P-ANCA: Microscopic Polyangiitis, Eosinophilic GPA (Churg
Anti-GBM Immune Complex ... Membranoproliferative • ↓C4: Lupus
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... immunofluorescence Immune Complex ... Post-strep GN, Lupus
A schema of the pathophysiology of the inborn errors of metabolism, excluding complex storage diseases. Helps
schema of the pathophysiology ... metabolism, excluding complex ... connections and pathophysiology ... MetabolicEmergency #Genetics #Pathophysiology