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hematology differential rheumatology syndrome algorithm workup gastroenterology hemeonc hemophagocytic hlh leukemia lymphohistiocytosis anemia cardiology cell chronic disorders foamed infectiousdiseases intravascular
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Artifact (redo CBC ... Myelogenous Leukemia • Primary ... • Rheumatic disorders ... effect following treatment ... #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... decreased PLT count: CBC ... not required in all ... unclear, or if a primary ... #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
old, ~10,000 new cases ... Allogeneic stem cell ... only curative treatment ... #Management #treatment ... #hematology #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Diagnosis: • ... lymphoproliferative disorders ... microglobulin Treatment ... #workup #oncology ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... + distinctive primary ... ) CLL Symptoms: ... #Leukemia #Hematology ... #Oncology #Diagnosis
Mucous Membrane Disorder - Differential Diagnosis Algorithm Erosions/Ulcers/Blisters - Primary Dermatologic Diseases •
Mucous Membrane Disorder ... - Differential Diagnosis ... Ulcers/Blisters - Primary ... • Squamous cell ... #Algorithm #causes
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
leukemia in adults • Disorder ... minimal tumor burden Diagnosis ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc ... #diagnosis #management
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... Chronic inflammatory disorders ... Post-splenectomy Primary ... myeloid leukemia (CML ... #Causes #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... ) (e.g. lupus, CLL ... usually IgM) (e.g. primary ... lymphoproliferative disorders
Post-Transplantation Lymphoproliferative Disorders (PTLD) Definition: Lymphoid and/or plasmacytic proliferations that occur as a result of immunosuppression in
Lymphoproliferative Disorders ... to 50% of PTLD cases ... Lymphoproliferative #Disorders ... #oncology #diagnosis ... #management #transplant
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