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hematology differential causes algorithm macrocytosis management activation cardiology erythematosus extravascular hemeonc hemolysis hemolytic hemophagocytic hlh intravascular lupus lymphohistiocytosis macrocytic macrophage
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
- Differential Diagnosis ... Increased Requirement (e.g ... Myelodysplastic Syndromes ... #Macrocytosis #elevatedMCV ... #Differential #Diagnosis
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
- Differential Diagnosis ... Iron Deficiency (Eg ... Other • e.g ... #Macrocytosis #elevatedMCV ... #Differential #Diagnosis
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... Toxic Damage (e.g ... Displacement (e.g ... Non-lmmune: • HELLP Syndrome ... Foreign Surface (e.g
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... (usually IgM) (e.g ... deficiencies (e.g ... Membrane defects (e.g ... #hematology #anemia
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
- Differential Diagnosis ... malignancies • Anemia ... inflammatory disorders (e.g ... Myelodysplastic syndrome ... #Causes #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
underlying disease (eg ... • Infection (eg ... with leukopenia, anemia ... #Diagnosis #Management ... #Hematology #Rheumatology
Palpitations - Differential Diagnosis Framework What? • It is an unpleasant awareness or sensation that the heart is
- Differential Diagnosis ... exam • 12-lead ECG ... Valvular disease (e.g ... Hyperthyroidism • Anemia ... /Afib/WPW) • Loss
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... • Malignancy (e.g ... Endocrine disorders (e.g ... lymphopenia, low PLT • Anemia ... #Rheumatology
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
- Differential Diagnosis ... Constitutional disorders, eg ... Chediak-Higashi syndrome ... Megaloblastic anemia-rare ... #causes #hematology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
▪ Infections (e.g ... - Cytopenias (anemia ... pro-inflammatory cytokines (e.g ... Immunosuppression (e.g ... anti-IFN-γ antibodies (e.g
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