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diagnosis differential syndrome treatment neurology algorithm rheumatology coagulation liver abnormal abscess anemia aptt barre blood dermatology guillain hepatitis intravascular lupus
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
factor activity (e.g ... clotting test (e.g ... Study #diagnosis #hematology ... #pathophysiology ... #hematology #laboratory
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... (usually IgM) (e.g ... deficiencies (e.g ... Membrane defects (e.g ... differential #diagnosis #hematology
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Management • ... Lymphoproliferative disorders (e.g ... Myeloproliferative disorders (e.g ... Syndrome #Diagnosis #Management ... #treatment #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Causes include : ... (e.g. heparin contamination ... inhibitory drugs (e.g ... specific inhibitor (e.g ... #differential #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
and Platelet Disorders ... Differential Diagnosis and ... function test, ANA (e.g ... or if a primary hematologic ... #Workup #hematology
Jaundice - Differential Diagnosis Algorithm Pre-Hepatic - Unconjugated Hyperbilirubinemia Increased Production • Hemolysis • Ineffective Erythropoiesis • Hematoma Decreased
Sepsis • Drugs (e.g ... Crigler-Najjar Syndromes (l and ... Diagnosis #Algorithm #Causes ... #Hepatology #bilirubinemia
Causes of Localized Lymphadenopathy - Differential Diagnosis Algorithm Cervical: - Anterior • Infection
Causes of Localized ... • Infection (e.g ... Infection (Forearm/Hand ... Diagnosis #Algorithm #Causes ... #Hematology #Oncology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Nonspecific inhibitors e.g ... to one factor e.g ... e.g. heparin ... inhibitory drugs e.g ... #differential #hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... high WBC count cause ... unless worrisome EKG ... TLS #diagnosis #management ... #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Increased Requirement (e.g ... • Rule out B12 and ... Diagnosis #Algorithm #Causes ... #Hematology
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