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Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Causes of Anemia ... Iron Deficiency (Eg ... Blood Loss, Occult ... Other • e.g ... #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
and Platelet Disorders ... plateletcount), peripheral blood ... function test, ANA (e.g ... or if a primary hematologic ... #Workup #hematology
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
factor activity (e.g ... clotting test (e.g ... Study #diagnosis #hematology ... #pathophysiology ... #hematology #laboratory
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... (usually IgM) (e.g ... deficiencies (e.g ... Membrane defects (e.g ... differential #diagnosis #hematology
Hypoxia and Hypoxemia - Overview Hypoxia - insufficient oxygen delivered to tissues to meet demands Hypoxemia - low
stagnant hypoxia (e.g ... carrying capacity (e.g ... abnormal hemoglobin (e.g ... cannot use oxygen (e.g ... #pathophysiology
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Management • ... Lymphoproliferative disorders (e.g ... Myeloproliferative disorders (e.g ... Syndrome #Diagnosis #Management ... #treatment #hematology
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
intake) • Target blood ... concentration: > 750ng/mL and ... Insufficient blood ... (e.g. renal failure ... levels #lupus #management
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Causes include : ... (e.g. heparin contamination ... inhibitory drugs (e.g ... specific inhibitor (e.g ... #differential #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Algorithm Normal Blood ... Increased Requirement (e.g ... • Rule out B12 and ... #Hematology
Consensus Indications for Irradiated RBC Transfusions: Cellular blood components are irradiated for the prevention of TA-GVHD. Transfused
Transfusions: Cellular blood ... - Intrauterine and ... HLA-selected products (e.g ... #Indications #Hematology ... #BloodBank #Management
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