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hepatology autoimmune hepatorenal hrs nephrology syndrome ah alcoholic biliary causes chronic cirrhosis differential dili druginduced erythematosus fatigue injury lupus management
Clinical diagnosis of Alcoholic Hepatitis (AH) • Onset of jaundice within prior 8 weeks • Ongoing
(e.g., severe upper ... use assessment (e.g ... laboratory tests (e.g ... #Hepatitis #AH ... #hepatology #criteria
Clinical Diagnosis of Autoimmune Hepatitis - Onset of jaundice within prior 8 weeks - Ongoing consumption
(e.g., severe upper ... use assessment (e.g ... laboratory tests (e.g ... #Diagnosis #Hepatology ... #AIH
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
inflammation (eg ... been reported (eg ... , AIH diagnosis ... Histology Findings (eg ... #AIH #Diagnosis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
DILI) - Stepwise Diagnosis ... Algorithm DILI ... of information (e.g ... vascular disorder (e.g ... #Algorithm #hepatology
Primary Biliary Cirrhosis - Diagnosis Algorithm Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort Signs: Jaundice, Xanthelasmata, Hepatomegaly Associated history:
autoimmune disease (e.g ... PBC if 2/3 criteria ... specific ANAs (e.g ... Liver biopsy findings ... #Algorithm #hepatology
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Algorithm Endocrine ... Renal Failure • Liver ... Neoplastic / Hematologic ... Epstein-Barr Virus • Hepatitis ... • Drug Abuse (e.g
Hepatorenal Syndrome Diagnosis • ↑ in serum Cr of ≥ 0.3mg/dL above baseline
severe and/or more gradual ... • Severe liver ... disease (e.g. advanced ... severe alcoholic hepatitis ... HRS #nephrology #criteria
Hepatorenal Syndrome (HRS) Definition: • Functional, potentially reversible kidney impairment. • Occurs in advanced liver disease: cirrhosis, severe alcoholic
severe alcoholic hepatitis ... sympathetic + ADH ... Criteria): • ↑ ... formerly Type 2): • Gradual ... insult (e.g., alcohol
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Malignancy (e.g ... . hematologic) ... Endocrine disorders (e.g ... Noninfectious hepatitis ... : • AIHA 10% •
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