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diagnosis hematology differential causes lymphadenopathy chronic diffuse focal localized lymphocytic workup anemia bandemia cancer cbc clinicopathology comparison enlarged hemeonc hemolytic
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Malaise, bleeding, infections ... extramedullary disease ... activity • ↓ LAP ... pain, bleeding, infections ... #Hematology #Oncology
Causes of Diffuse and Localized Lymphadenopathy - Differential Diagnosis Algorithm • Reactive (Inflammatory / Infectious) •
Inflammatory / Infectious ... • Neoplastic (Leukemia ... Lymphadenopathy #LAD ... #Causes #Hematology ... #Oncology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Differential Diagnosis Algorithm ... Pseudotumor - Infectious ... Lymphadenopathy #LAD ... #Causes #Hematology ... #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
weeks without infection ... cells can indicate disease ... leukemia #CLL ... diagnosis #workup #oncology ... #hematology
Causes of Localized Lymphadenopathy - Differential Diagnosis Algorithm Cervical: - Anterior • Infection
Differential Diagnosis Algorithm ... • Kikuchi Disease ... Lymphadenopathy #LAD ... #Causes #Hematology ... #Oncology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Differential Diagnosis Algorithm ... Infectious • ... • Lymphoma • Leukemia ... • Sickle Cell ... #Causes #Hematology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
e.g., HIV), EBV infection ... involved) • No leukemic ... Etiology: - Infections ... NonHodgkins #comparison #oncology ... #differential #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
(CLL) - Summary ... Complications: 1) Infection ... chemotherapy for low-risk disease ... uw_IMresidency #CLL ... #oncology #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... Consider sickle cell ... nucleotidase deficiency, lead ... inclusions - If infection ... #workup #hematology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Left Shift: • Cell ... Tissue damage • Leukemia ... • Autoimmune diseases ... overlook severe infections ... neutrophil #WBC #CBC #hematology
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