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diagnosis rheumatology differential autoimmune lupus myopathy pathophysiology sle systemic vasculitis complications disorders lymphomas lymphoproliferative management musculoskeletal nonhodgkin sams signs statin
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... - Myositis ... Systemic #Lupus #Erythematosus ... #SLE #MSK #Musculoskeletal ... pathophysiology #signs #symptoms
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... associated with higher CK ... greater level of muscle ... less systemic symptoms ... #diagnosis #rheumatology
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
Symptoms (SAMS) ... • Myalgia • Myositis ... systemic lupus erythematosus ... inclusion body myositis ... Diagnosis: • CK
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... (SCLE): • Photosensitive ... Malignancy (e.g. hematologic ... • Transverse Myelitis ... Induced Lupus: • Symptoms
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... Tests: • Measure CK ... (symmetric) • CK ... weakness • CK ... #Myopathy #rheumatology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Differential Diagnosis Algorithm ... pattern of spread, B symptoms ... Amy Chung, MD, MSc ... Lymphoproliferative #Disorders #Classification ... pathophysiology #Hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
ischemia - Skin: erythematous ... Joints: myalgia and muscle ... systemic lupus erythematosus ... Presentation - Systemic Symptoms ... #classification
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Presentation: Systemic Symptoms ... shoulder and hip • Muscle ... ischemia • Skin: Erythematous ... Conjunctivitis, mucositis ... • Progressive symptoms
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