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differential rheumatology autoimmune erythematosus lupus management myopathy neurology orthopedics systemic vasculitis chronic complications cord creatine disorders elevated fractures fragility intraarticular
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
- Myositis ... Myopathy (Also caused ... #MSK #Musculoskeletal ... pathophysiology #signs #symptoms ... #diagnosis
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
associated with higher CK ... greater level of muscle ... less systemic symptoms ... /full triad at diagnosis ... Can also see mechanics
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
Creatine Kinase - Causes ... ): • PROXIMAL MUSCLE ... tissue disorder, SLE ... Inclusion body myositis ... #differential #diagnosis
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
• Myalgia • Myositis ... erythematosus (SLE ... inclusion body myositis ... Atorvastatin Diagnosis ... : • CK: - SAMS
Chronic Joint Pain - Differential Diagnosis Algorithm Intra-Articular - Bone • Stress
- Differential Diagnosis ... Algorithm Intra-Articular ... Fibromyalgia • Myositis ... Intraarticular #MSK ... #Causes
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
- Differential Diagnosis ... Non-compressive Spinal Cord Causes ... - Transverse myelitis ... Behcet disease - SLE ... differential #algorithm
Pathologic / Fragility Fractures - Differential Diagnosis Algorithm Tumours - See Bone Lesions Scheme Paget's Disease -
Algorithm Tumours ... - See Bone Lesions ... Pain/Proximal Muscle ... Fractures #Pathologic #MSK ... #Causes
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Bilateral signs and/or symptoms ... Diagnosis: • ... Evaluate for NMO, SLE ... • Infectious causes ... Disorders: - SLE
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... - Differential Diagnosis ... myopathies Diagnostic ... statins - probably caused ... #differential #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... erythematosus (SCLE ... Differential Diagnosis ... Induced Lupus: • Symptoms ... Erythematosus #Diagnosis
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