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diagnosis differential rheumatology autoimmune management neurology complications cord creatine disorders elevated erythematosus kinase lupus musculoskeletal myelitis pathophysiology rhabdomyolysis sams signs
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
- Myositis ... femoral heads • Myopathy ... (Also caused by ... #MSK #Musculoskeletal ... pathophysiology #signs #symptoms
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
Creatine Kinase - Causes ... Subacute to Chronic Causes ... ): • PROXIMAL MUSCLE ... tissue disorder, SLE ... Inclusion body myositis
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Necrotizing myopathy ... associated with higher CK ... greater level of muscle ... less systemic symptoms ... Can also see mechanics
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
Symptoms (SAMS) ... • Myalgia • Myositis ... erythematosus (SLE ... inclusion body myositis ... Diagnosis: • CK
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... Tests: • Measure CK ... (symmetric) • CK ... weakness • CK ... statins - probably caused
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
findings: • Symptoms ... Non-compressive Spinal Cord Causes ... - Transverse myelitis ... Behcet disease - SLE ... differential #algorithm
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
the spinal cord (Myelopathy ... Bilateral signs and/or symptoms ... Evaluate for NMO, SLE ... • Infectious causes ... Disorders: - SLE
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... Joints: myalgia and muscle ... Presentation - Systemic Symptoms ... vasculitis, and SLE ... #rheumatology #classification
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