22 results
diagnosis differential management rheumatology neurology clinical algorithm autoimmune erythematosus lupus myopathy orthopedics ossificans pathophysiology physicalexam pocus sle systemic thigh transverse
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
- Myositis ... Weakness, Incr CK ... Myopathy (Also caused ... Erythematosus #SLE #MSK ... pathophysiology #signs #symptoms
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... associated with higher CK ... greater level of muscle ... less systemic symptoms ... triad of ILD, myositis
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
Creatine Kinase - Causes ... of Elevated CK ... Subacute to Chronic Causes ... ): • PROXIMAL MUSCLE ... Inclusion body myositis
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
Symptoms (SAMS) ... symptoms: weeks ... • Myalgia • Myositis ... inclusion body myositis ... Diagnosis: • CK
Chronic Joint Pain - Differential Diagnosis Algorithm Intra-Articular - Bone • Stress
Fasciitis) - Muscle ... Delayed Onset Muscle ... Fibromyalgia • Myositis ... Intraarticular #MSK ... #Orthopedics #Causes
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... Tests: • Measure CK ... (symmetric) • CK ... weakness • CK ... statins - probably caused
Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Causes of Neuromuscular ... Demyelinating Disease (MS ... Tetanus, Transverse Myelitis ... aminoglycosides) • Muscles ... Neuromuscular #Weakness #Causes
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
findings: • Symptoms ... Hyperreflexia - Muscle ... equina- decreased muscle ... Non-compressive Spinal Cord Causes ... - Transverse myelitis
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
: • 1400 new cases ... 10-33% develop MS ... • 75-90% of cases ... Bilateral signs and/or symptoms ... • Infectious causes
Leg Pain - Differential Diagnosis Framework Bone/Joint Causes of Leg Pain: • Fracture • Arthritis • Gout/pseudogout
Bone/Joint Causes ... Lyme disease Muscle ... Causes of Leg Pain ... Compartment syndrome • Myositis ... lower #extremity #msk
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