72 results
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
- Myositis ... Weakness, Incr CK ... Myopathy (Also caused ... Erythematosus #SLE #MSK ... pathophysiology #signs #symptoms
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... associated with higher CK ... greater level of muscle ... less systemic symptoms ... triad of ILD, myositis
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
Creatine Kinase - Causes ... immobility • Critical ... Subacute to Chronic Causes ... ): • PROXIMAL MUSCLE ... Inclusion body myositis
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
Toxicity - Summary Clinical ... • Myalgia • Myositis ... inclusion body myositis ... Diagnosis: • CK ... IU/I • SAMS clinical
Chronic Joint Pain - Differential Diagnosis Algorithm 
Intra-Articular
 - Bone
     • Stress
Fasciitis) - Muscle ... Delayed Onset Muscle ... Fibromyalgia • Myositis ... Intraarticular #MSK ... #Orthopedics #Causes
Hypothyroid Myopathy
Very common (up to 80% ) in patients with hypothyroidism
Pathophysiology:
 • T4 deficiency leads to
which impairs musde ... fibers Spectrum of Clinical ... Asymptomatic CK ... proximal myopathy → Muscle ... pathophysiology #signs #symptoms
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Causes of Neuromuscular ... Demyelinating Disease (MS ... Tetanus, Transverse Myelitis ... heavy metals), Critical ... aminoglycosides) • Muscles
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... Tests: • Measure CK ... (symmetric) • CK ... weakness • CK ... statins - probably caused
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings
Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
Pathogenesis and clinical ... - Elevation of muscle ... Creatinine kinase (CK ... - Bilateral Muscle ... Pathophysiology #Signs #Symptoms
Anterior Shoulder Dislocation: Pathogenesis, clinical, and radiographic findings

Trauma, Fall on, outstretched arm, Overhead throwing => Abduction
Pathogenesis, clinical ... tensile strength of muscle ... damage to nerves, muscles ... Diagnosis #signs #symptoms ... #msk #orthopedics