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diagnosis differential disorders management neurology rheumatology ascorbicacid autoimmune chronic complications cord erythematosus hematology intraarticular jointpain lupus lymphomas lymphoproliferative musculoskeletal myelitis
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
- Myositis ... Myopathy (Also caused ... Erythematosus #SLE #MSK ... Complications #pathophysiology ... #signs #symptoms
Chronic Joint Pain - Differential Diagnosis Algorithm Intra-Articular - Bone • Stress
Differential Diagnosis Algorithm ... Fasciitis) - Muscle ... Fibromyalgia • Myositis ... Intraarticular #MSK ... #Orthopedics #Causes
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... Tests: • Measure CK ... (symmetric) • CK ... weakness • CK ... statins - probably caused
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
findings: • Symptoms ... Hyperreflexia - Muscle ... Non-compressive Spinal Cord Causes ... - Transverse myelitis ... differential #algorithm
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
: • 1400 new cases ... 10-33% develop MS ... monophasic Pathophysiology ... Bilateral signs and/or symptoms ... • Infectious causes
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Differential Diagnosis Algorithm ... pattern of spread, B symptoms ... Amy Chung, MD, MSc ... Lymphoproliferative #Disorders #Classification ... #pathophysiology
Scurvy (Vitamin C Deficiency) - Diagnosis and Management Vitamin C is required for hydroxylation of proline residues
musculoskeletal symptoms ... Psychiatric symptoms ... nonimmune hemolysis MSK ... • Weakness • Muscle ... , or any other cause
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... Joints: myalgia and muscle ... Conjunctivitis, mucositis ... Presentation - Systemic Symptoms ... #rheumatology #classification
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