15 results
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... - Myositis ... Erythematosus #SLE #MSK ... Complications #pathophysiology ... #signs #symptoms
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... associated with higher CK ... greater level of muscle ... weakness, less systemic ... symptoms, and less
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
• Myalgia • Myositis ... syndrome (GBS), systemic ... inclusion body myositis ... Diagnosis: • CK ... myopathy #diagnosis #management
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... Tests: • Measure CK ... (symmetric) • CK ... weakness • CK ... • Conduction system
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
with lymphatic system ... pattern of spread, B symptoms ... Amy Chung, MD, MSc ... Lymphoproliferative #Disorders #Classification ... #pathophysiology
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
10-33% develop MS ... monophasic Pathophysiology ... Bilateral signs and/or symptoms ... Predictive of MS ... #diagnosis #management
Multiple Sclerosis - Summary

Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
central nervous system ... neuritis • Partial myelitis ... defect SIGNS/SYMPTOMS ... Signs and symptoms ... sclerosis #diagnosis #management
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
lateral sclerosis Pathophysiology ... of the nervous system ... , muscle atrophy ... fasciculations Common Symptoms ... neurology #diagnosis #management
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Joints: myalgia and muscle ... Conjunctivitis, mucositis ... central nervous system ... Symptoms (Sx) in ... #rheumatology #classification
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Diagnosis and Management ... survival is 93-95% Pathophysiology ... the lymphatic system ... anterior/posterior MSK ... 5-10%, nervous system