121 results
Cushing Syndrome Testing Algorithm
INDICATIONS FOR TESTING:
 • Suspected Cushing syndrome (central obesity, muscle weakness, refractory hypertension)
Testing:
Cushing Syndrome ... Testing Algorithm ... central obesity, muscle ... #diagnosis #algorithm ... #endocrinology
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Weakness, Normal CK ... Weakness, Incr CK ... Erythematosus #SLE #MSK ... pathophysiology #signs #symptoms ... #diagnosis
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
Guillain-Barré syndrome ... antisynthetase syndrome ... Atorvastatin Diagnosis ... : • CK: - SAMS ... toxicity #myopathy #diagnosis
Hypothyroid Myopathy
Very common (up to 80% ) in patients with hypothyroidism
Pathophysiology:
 • T4 deficiency leads to
which impairs musde ... Asymptomatic CK ... proximal myopathy → Muscle ... pathophysiology #signs #symptoms ... #endocrinology
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
associated with higher CK ... greater level of muscle ... less systemic symptoms ... anti-synthetase syndrome ... /full triad at diagnosis
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm
No Objective Weakness
 • Cardio-pulmonary disease
- Differential Diagnosis ... Algorithm No Objective ... Lambert-Eaton Myasthenic Syndrome ... Myopathy - Proximal muscle ... involvement, elevated CK
Causes of Peripheral Weakness - With and Without Sensory Changes - Differential Diagnosis Algorithm
With Sensory Changes:
- Differential Diagnosis ... Algorithm With ... Myopathy - Proximal muscle ... involvement, elevated CK ... #Algorithm #Causes
Diabetes Insipidus vs Syndrome of Inappropriate ADH (SIADH) - Comparison Table

Diabetes Insipidus - Inadequate ADH
SIADH -
Diabetes Insipidus vs Syndrome ... Pathophysiology #Signs #Symptoms ... #Diagnosis #Endocrinology
Hypothyroidism – symptoms and signs.

Symptoms: 
Tiredness/malaise, 
Weight gain,
Anorexia,
Cold intolerance, 
Poor memory,
Change in appearance, 
Depression, 
Poor libido,
Symptoms: Tiredness ... , Myalgia, Muscle ... Carpal timel syndrome ... #Diagnosis #PhysicalExam ... #Endocrinology
Cubital Tunnel Syndrome: Pathogenesis and clinical findings

 • Paresthesia of 5th and medial half of 4th
Cubital Tunnel Syndrome ... • Hypothenar muscle ... #Diagnosis #pathophysiology ... #signs #symptoms ... #msk