39 results
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... (SLE): Musculoskeletal ... Erythematosus #SLE ... #MSK #Musculoskeletal ... pathophysiology #signs #symptoms
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... associated with higher CK ... greater level of muscle ... weakness, less systemic ... symptoms, and less
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
Causes of Elevated CK ... Levels Acute CK ... ): • PROXIMAL MUSCLE ... myopathy - Autoimmune ... tissue disorder, SLE
Joint Disorders - Differential Diagnosis Algorithm
Monoarthritis
 • Septic
 • Crystalline
     - Gout
autoimmune disease ... Lupus - with Systemic ... Erythematosus (SLE ... should have other symptoms ... Joint #Disorders #msk
Systemic Lupus Erythematosus: Gastrointestinal Manifestations
 - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... the pancreas, Vasculitis ... distension #Systemic ... Erythematosus #SLE ... pathophysiology #signs #symptoms
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
Symptoms (SAMS) ... syndrome (GBS), systemic ... erythematosus (SLE ... syndrome (LEMS), systemic ... Diagnosis: • CK
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features of Systemic ... Lupus (SLE) General ... Butterfly rash, Vasculitis ... Thrombocytopenia #Lupus #SLE ... #signs #symptoms
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Joints: myalgia and muscle ... central nervous system ... Presentation - Systemic ... Symptoms (Sx) in ... , and SLE) • Urinalysis
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Positive ANA ≠ Autoimmune ... context of other symptoms ... erythematosus (SLE ... Disorders, Infection, Autoimmune ... Thyroid, Autoimmune
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... infection • Autoimmune ... diseases: - 10% SLE ... disorder (e.g. systemic ... erythematosus (SLE