43 results
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... Weakness, Incr CK ... Osteoporosis #Systemic ... Erythematosus #SLE #MSK ... pathophysiology #signs #symptoms
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
Guillain-Barré syndrome ... (GBS), systemic ... antisynthetase syndrome ... (LEMS), systemic ... Diagnosis: • CK
Parkinson's Plus Syndromes - Atypical Parkinsonism
Main motor symptoms:
 • Tremors
 • Limb rigidity
 • Bradykinesia
Other symptoms
Parkinsonism Main motor symptoms ... Bradykinesia Other symptoms ... : • Multiple system ... atrophy (MSA) ... Parkinsonism #diagnosis #neurology
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
associated with higher CK ... greater level of muscle ... weakness, less systemic ... symptoms, and less ... anti-synthetase syndrome
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear

Visual or auditory symptoms in conjunction
Visual or auditory symptoms ... conjunction with symptoms ... central nervous system ... • Systemic lupus ... #neurology #inflammatory
Guillain-Barre Syndrome
An acute polyneuropathy (disorder Of the peripheral nervous System).
Symptoms are Often symmetrical and progress Over
Guillain-Barre Syndrome ... peripheral nervous System ... Symptoms are Often ... GuillainBarre #Syndrome ... #Diagnosis #Neurology
Joint Disorders - Differential Diagnosis Algorithm
Monoarthritis
 • Septic
 • Crystalline
     - Gout
arthritis - (Reiter’s syndrome ... Lupus - with Systemic ... should have other symptoms ... Amy Chung, MD, MSc ... Joint #Disorders #msk
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm
No Objective Weakness
 • Cardio-pulmonary disease
Lambert-Eaton Myasthenic Syndrome ... Myopathy - Proximal muscle ... involvement, elevated CK ... Peripheral #Weakness #Neurology
BEE Syndromes - Non-inflammatory Causes

Immune-mediated conditions affecting the Brain, Eye, and Ear

Visual or auditory symptoms in
Visual or auditory symptoms ... conjunction with symptoms ... central nervous system ... consistent with MS ... #neurology #noninflammatory
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
• Acute stroke syndromes ... central nervous system ... Peripheral Nervous System ... Paraneoplastic syndrome ... Differential #Diagnosis #neurology