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diagnosis differential rheumatology symptoms pathophysiology rhabdomyolysis table autoimmune causes comparison dermatomyositis management myopathy myositis nephrology workup acute acutemyocardialinfarction aki algorithm
RHABDOMYOLYSIS • Characterized by skeletal muscle breakdown & necrosis. • Elevated Creatine kinase (CK) hallmark of rhabdomyolysis. • Defined based
Creatine kinase (CK ... Defined based on CK ... • Half-life of CK ... • Myoglobin half-life ... metabolism makes myoglobin
Creatine kinase (CK) is an intracellular enzyme present in skeletal muscle, myocardium & brain; smaller amounts
Creatine kinase (CK ... Myoglobin levels ... Myoglobin has a ... metabolism makes serum myoglobin ... #myoglobin
Acute Myocardial Infarction - Biomarker time course #Diagnosis #Cardiology #AcuteMyocardialInfarction #AMI #Biomarkers #Enzymes #Troponins #CKMB #Myoglobin
Enzymes #Troponins #CKMB ... #Myoglobin #Trends
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
clinical context and signs ... Rhabdo-myolysis: CK ... , myoglobin • ... syndrome: troponin, CK-MB
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Weakness, Normal CK ... Weakness, Incr CK ... therapy), Normal CK ... pathophysiology #signs
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
: Proximal • CK ... heliotrope, shawl sign ... : Proximal • CK ... : Proximal • CK ... and distal • CK
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
associated with higher CK ... heliotrope rash, Shaw sign ... , holster sign,
Rapid, increasing signs of extrapyramidal symptoms (EPS) is an important key feature of NMS. EPS, associated
Rapid, increasing signs ... creatine kinase (CK
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
Creatinine kinase (CK ... Pathophysiology #Signs
Hypothyroid Myopathy Very common (up to 80% ) in patients with hypothyroidism Pathophysiology: • T4 deficiency leads to
Asymptomatic CK ... pathophysiology #signs
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