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diagnosis hematology treatment differential activation all autoimmune behcet causes chronic cll coagulation dehydrogenase dic disseminated elevated emergencies erythematosus fungal hemeonc
Treatment Schema for Standard-Risk Acute Lymphoblastic Leukemia Induction: • Vincristine, Steroid (dexamethasone), L-Asparaginase, Intrathecal (IT) methotrexate Consolidation
Standard-Risk Acute ... Consolidation & CNS ... Treatment #timeline #oncology ... #pediatrics #peds ... #management
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... involvement • 30%: CNS ... : CNS manifestations ... • Tumor lysis syndrome ... #Hematology #Oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... risk-stratification • Risks: infection ... transformation to acute ... leukemia Management ... #oncology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
basal ganglia, CNS ... meningitis), MCC CNS ... tears, Ischemia, Leukemia ... collaboration • CNS ... #diagnosis #management
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
if SSTI or port infection ... antibiotics TLS ... Usually myeloid leukemias ... ) - Symptoms: CNS ... ) - Symptoms: CNS
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
weeks without infection ... cells can indicate disease ... ’s lymphoma or acute ... diagnosis #workup #oncology ... #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: • Acute ... fibromyalgia) • Infections ... Pleural effusions • Acute ... and CNS • Headache ... Hodgkin lymphoma and leukemia
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... nervous system (CNS ... SLE], AOSD) • Infection ... #Diagnosis #Management ... #Hematology #Rheumatology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Injury: • Early acute ... hepatitis • Acute ... Periodic paralyses CNS ... • Toxins • Infection ... Lymphomas • Leukemias
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
presents with acute ... pulmonary symptoms • Rheumatologic ... especially the CNS ... MC: CNS CSF: • ... Fungal #Diagnosis #Management
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