13 results
diagnosis differential hematology treatment leukemia activation acute agglutinin algorithm anemia autoimmune behcet causes cerebritis cold cranial erythematosus hemolytic hemophagocytic hlh
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... involvement • 30%: CNS ... : CNS manifestations ... • Tumor lysis syndrome ... #Oncology #Diagnosis
Treatment Schema for Standard-Risk Acute Lymphoblastic Leukemia Induction: • Vincristine, Steroid (dexamethasone), L-Asparaginase, Intrathecal (IT) methotrexate Consolidation
Consolidation & CNS ... Cytarabine #ALL ... Treatment #timeline #oncology ... #pediatrics #peds ... #management
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Lymphoma (HCV) • CLL ... • Heavy Chain disease ... Scleromyxedema (CNS ... Sneddon-Wilkinson disease ... Differential #Diagnosis #Oncology
Hypoxemia / Hypoxia - Rapid Response Management Algorithm Stridor - Upper airway pathology: • Anaphylaxis • Foreign
Rapid Response Management ... asthma • Pleural disease ... Hypoventilation: • CNS ... e.g., GBS, MG, ALS ... differential #Diagnosis #Management
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
basal ganglia, CNS ... meningitis), MCC CNS ... collaboration • CNS ... #diagnosis #management ... signs #symptoms #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Demyelinating Syndrome ... Cerebrovascular Disease ... Erythematosus #SLE #CNS ... #neurology #rheumatology
Multiple Cranial Neuropathies - High Yield Differential Diagnosis • Intrinsic brainstem process • Compressive brainstem process
Neurosarcoidosis • CNS ... Lyme Disease, TB ... Miller Fisher Syndrome ... variant-GBS • Bulbar ALS
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Parotid swelling CNS ... nervous system (CNS ... • 8%-27% for CNS ... #Rheumatology # ... Diagnosis #Management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... nervous system (CNS ... tests ↑ AST ↑ ALT ... #Diagnosis #Management ... #Hematology #Rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Disease ... Cold Agglutinin Syndrome ... (CAS): - Due ... hemolysis • C3↓ C4 ... hemolytic #anemia #hematology
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